Who am I to suggest Lil Wayne doesn't know tennis?
From prison, he still gives us (courtesy of Sports Illustrated) his picks for the championship (as well as some commentary about the other players) right here.
Care to take Lil Wayne's breakdown and apply it to your own U.S. Open bracket? Go for it! (Quick aside - the user interface for the brackets might be the worst thing I've ever seen. Still, it's also the only tennis bracket online I've seen, so I guess I can't get too mad.