I love how he goes from a chipmunk to Penn Jillette simply with the inhaling of different gases. Not sure if this was on Mythbusters or not - I've never seen it.
There's so much bad here, I think the worst is that this is obviously fake. What for, I have no idea. A commercial maybe? I could probably wade into the comments section to find out, but seriously have you ever read the comments section on youtube?
Just a quick look at a number of different computer effects. I really can't describe it any other way.